Reaktion #2285068

Reaktionsgleichung

product

5-Chloro-2-methyl-[1,8]naphthyridine

product

N-{4-[2-Amino-4-(3-bromo-benzyloxy)-phenylsulfanyl]-phenyl}-acetamide

→

crude title compound

N-{4-[4-(3-Bromo-benzyloxy)-2-(7-methyl-[1,8]naphthyridin-4-ylamino)-phenylsulfanyl]-phenyl}-acetamide

Lösungsmittel

ethanol

Reaktionsbedingungen

Vorschrift

The product from Example 1d (18 mg, 0.085 mmol) was reacted in ethanol (1 mL) with the product from Example 154a (37 mg, 0.085 mmol) for 18 h following the procedure from Example 1g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid salt (15 mg, 30%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 0.97 (t, J=7.35 Hz, 3H) 1.65-1.90 (m, 2H) 2.02 (s, 3H) 2.99 (t, J=7.54 Hz, 2H) 5.17 (s, 2H) 6.29 (d, J=6.99 Hz, 1H) 7.14 (d, J=8.82 Hz, 2H) 7.17-7.27 (m, 2H) 7.28-7.40 (m, 3H) 7.42 (d, J=8.46 Hz, 2H) 7.55 (d, J=7.72 Hz, 1H) 7.66 (s, 1H) 7.80 (d, J=8.46 Hz, 1H) 8.37 (d, J=6.99 Hz, 1H) 8.97 (d, J=8.82 Hz, 1H) 9.98 (s, 1H) 11.00 (s, 1H) 14.37 (s, 1H); MS (ESI+) m/z 613 (M+H)+.

Quelle