Reaktion #2281980

Reaktionsgleichung

1-bromo-3-methoxy-5-methyl-benzene

DMF

→

solid

Ausbeute 83.0%

3-Methoxy-5-methyl-benzonitrile

Ausbeute 83.0%

Lösungsmittel

Ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenby washing with brine
2. 2
   EinengenThe organic layer was concentrated
3. 3
   Sonstigepurified (silica gel, 0-50% EtOAC/hexane)

Vorschrift

In a 100 mL round bottom flask, 1-bromo-3-methoxy-5-methyl-benzene (2.17 g, 10.79 mmol), Zn(CN)2 (1.9 g, 16.19 mmol, 1.5 eq.) and Pd(PPh3)4 (1.24 g, 1.08 mmol, 0.1 eq.) was charged with DMF (20 mL). The reaction mixture was heated at 90° C. under Ar for 7 hours. Ethyl acetate was added, followed by washing with brine. The organic layer was concentrated and purified (silica gel, 0-50% EtOAC/hexane) to give a white solid (1.31 g, 83%). 1H NMR (300 MHz, CDCl3): δ 7.05 (s, 1H), 6.97 (s, 2H), 3.81 (s, 3H), 2.39 (s, 3H).

Quelle