Reaktion #2275741

ord-703923a66d214963b6babd6c8905177a

Reaktionsgleichung

O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide
COc1cccn(C2CCC(=O)CC2)c1=O
3-methoxy-1-(4-oxo-cyclohexyl)-1H-pyridin-2-one
COc1cccn(C2CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1=O
title compounds
COc1cccn(C2CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1=O
N-({1-[4-(3-Methoxy-2-oxo-2H-pyridin-1-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compounds were prepared as white solids from the reductive amination of 3-methoxy-1-(4-oxo-cyclohexyl)-1H-pyridin-2-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08324186B2uspto-grants-2012_12