Reaktion #2275730

ord-9090364a6c5c4c03890e29499f43e035

Reaktionsgleichung

O=C1CCC(Oc2ccccn2)CC1
4-(pyridin-2-yloxy)-cyclohexanone
O=C1CCC(Oc2ccccn2)CC1
4-(Pyridin-2-yloxy)-cyclohexanone
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(Oc3ccccn3)CC2)C1
title compounds
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(Oc3ccccn3)CC2)C1
N-({1-[4-(Pyridin-2-yloxy)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeas prepared in the previous step)

Vorschrift

The title compounds were prepared as white solids from the reductive amination of 4-(pyridin-2-yloxy)-cyclohexanone (as prepared in Step A) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in the previous step) using the procedure described in Step D of Example 1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08324186B2uspto-grants-2012_12