Reaktion #2275196

Reaktionsgleichung

2-hydroxy-6-methyl-benzoic acid ethyl ester

t-butyl-di-methylsilyl chloride

diisopropyl ethylamine

→

2-(tert-butyl-dimethyl-silanyloxy)-6-methyl-benzoic acid ethyl ester

Ausbeute 93.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water, brine
2. 2
   Trocknendried (MgSO4)
3. 3
   Filtrationfiltered
4. 4
   Sonstigethe solvent evaporated in vacuo, which

Vorschrift

To a solution of 2-hydroxy-6-methyl-benzoic acid ethyl ester (5.00 g, 27.8 mmol) and t-butyl-di-methylsilyl chloride (6.27 g, 41.6 mmol) in dichloromethane (100 ml) was added diisopropyl ethylamine. The solution was stirred at 50° C. for 24 hours, washed with water, brine, dried (MgSO4), filtered and the solvent evaporated in vacuo, which afforded 7.6 g (93%) of 2-(tert-butyl-dimethyl-silanyloxy)-6-methyl-benzoic acid ethyl ester as an oil.

Quelle