Reaktion #2270849

Reaktionsgleichung

sodium hydrogencarbonate

3-(benzo[b]thiophen-5-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide

→

3-(benzo[b]thiophen-5-yl)-5,6-dihydroimidazo[2,1-b]thiazole

Ausbeute 96.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe organic layer was separated
2. 2
   Waschenwashed with water (2×75 ml) and saturated aqueous sodium chloride solution (75 ml)
3. 3
   Trocknendried (MgSO4)
4. 4
   Sonstigethe solvent was removed in vacuo

Vorschrift

Saturated aqueous sodium hydrogencarbonate solution (100 ml) was added over 10 minutes to a stirred suspension of 3-(benzo[b]thiophen-5-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (2.6 g) in dichloromethane (100 ml), the mixture was stirred at ambient temperature for 45 minutes, then the organic layer was separated, washed with water (2×75 ml) and saturated aqueous sodium chloride solution (75 ml), dried (MgSO4) and the solvent was removed in vacuo to give 3-(benzo[b]thiophen-5-yl)-5,6-dihydroimidazo[2,1-b]thiazole (1.9 g) as an orange solid which was used without further purification.

Quelle