Reaktion #2270835

Reaktionsgleichung

bromine

3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[-2,1-b]thiazole

→

3-(benzo[b]thiophen-4-yl)-2-bromo-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe resulting solid was collected by filtration
2. 2
   Waschenwashed with dichloromethane (20 ml)
3. 3
   Sonstigedried in vacuo at 40-50° C.

Vorschrift

A solution of bromine (0.30 ml) in dichloromethane (15 ml) was added dropwise under nitrogen at 0-5° C. to a stirred solution of 3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[-2,1-b]thiazole (1.45 g) in dichloromethane (40 ml), then the mixture was stirred at ambient temperature for 1 hour. The resulting solid was collected by filtration, washed with dichloromethane (20 ml) and dried in vacuo at 40-50° C. to give 3-(benzo[b]thiophen-4-yl)-2-bromo-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (2.3 g) as a pale yellow solid, m.p. 229-235° C.

Quelle