Reaktion #2270834

Reaktionsgleichung

sodium hydrogencarbonate

3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide

→

3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole

Ausbeute 80.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe organic phase was separated
2. 2
   Waschenwashed with water (50 ml) and saturated aqueous sodium chloride solution (50 ml)
3. 3
   Trocknendried (Na2SO4)
4. 4
   Sonstigethe solvent was removed in vacuo

Vorschrift

Saturated aqueous sodium hydrogencarbonate solution (100 ml) was added at 0° C. to a stirred suspension of 3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (2.38 g) in dichloromethane (50 ml), and the mixture was stirred at ambient temperature for 2 hours. The organic phase was separated, washed with water (50 ml) and saturated aqueous sodium chloride solution (50 ml), dried (Na2SO4), and the solvent was removed in vacuo to give 3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole (1.45 g) as a yellow solid which was used without further purification.

Quelle