Reaktion #2270808

Reaktionsgleichung

N-methoxy-N-methylbutyramide

magnesium

4-bromo-benzo[b]thiophene

iodine

hydrochloric acid

4-bromobenzo[b]thiophene

→

1-(benzo[b]thiophen-4-yl)butan-1-one

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeprepared in a manner similar to
2. 2
   Temperaturthe mixture was heated
3. 3
   Sonstigethe reaction
4. 4
   Temperaturat reflux temperature over 15 minutes
5. 5
   Temperaturthe mixture was heated
6. 6
   Temperaturunder reflux 20 minutes
7. 7
   Temperaturthe mixture was heated
8. 8
   Temperaturunder reflux for 50 minutes
9. 9
   Temperaturto cool to ambient temperature
10. 10
    Extraktionthe product was extracted into ethyl acetate (100 ml)
11. 11
    WaschenThe extract was washed with water (50 ml) and saturated aqueous sodium chloride solution (2×50 ml)
12. 12
    Trocknendried (Na2SO4)
13. 13
    Sonstigethe solvents were removed in vacuo
14. 14
    SonstigeThe residue was purified by flash chromatography over silica using
15. 15
    workup.ADDITIONa 96:4 mixture of petroleum ether (b.p. 60-80° C.) and ethyl acetate as eluant
16. 16
    Sonstigethe solvents removed in vacuo

Vorschrift

Approximately 5 ml of a solution of 4-bromobenzo[b]thiophene (1.85 g; prepared in a manner similar to that described in Bull. Soc. Chim. Fr., 1966, 111, 3667) in tetrahydrofuran (20 ml) was added under nitrogen to magnesium turnings (0.22 g) in tetrahydrofuran (2 ml). Two crystals of iodine were added, and the mixture was heated to initiate the reaction. The remainder of the 4-bromo-benzo[b]thiophene solution was added at reflux temperature over 15 minutes, then the mixture was heated under reflux 20 minutes and allowed to cool to ambient temperature. A solution of N-methoxy-N-methylbutyramide (1.13 g) in tetrahydrofuran (10 ml) was added, the mixture was heated under reflux for 50 minutes, then it was allowed to cool to ambient temperature and 2M hydrochloric acid (25 ml) was added. The mixture was stirred at ambient temperature for 1 hour, then the product was extracted into ethyl acetate (100 ml). The extract was washed with water (50 ml) and saturated aqueous sodium chloride solution (2×50 ml), dried (Na2SO4), and the solvents were removed in vacuo. The residue was purified by flash chromatography over silica using a 96:4 mixture of petroleum ether (b.p. 60-80° C.) and ethyl acetate as eluant. Appropriate fractions were combined and the solvents removed in vacuo to give 1-(benzo[b]thiophen-4-yl)butan-1-one (0.41 g) as a colourless oil which was used without further purification.

Quelle