Reaktion #2270775

Reaktionsgleichung

Bromine

3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole

→

3-(benzo[b]thiophen-4-yl)-2-bromo-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe resulting solid was collected by filtration
2. 2
   Waschenwashed with dichloromethane (30 ml)
3. 3
   Sonstigedried in vacuo at 60° C.

Vorschrift

Bromine (0.16 ml) was added dropwise at 0-5° C. over 5 minutes to a stirred solution of 3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole (0.8 g; prepared by basification of 1 g of the hydrochloride salt described in Example 2) in dichloromethane (50 ml), then the mixture was stirred at 0° C. for 10 minutes and at ambient temperature for 1.5 hours. The resulting solid was collected by filtration, washed with dichloromethane (30 ml) and dried in vacuo at 60° C. to give 3-(benzo[b]thiophen-4-yl)-2-bromo-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (1.28 g) as a pale yellow solid which was used without further purification.

Quelle