Reaktion #2269083

Reaktionsgleichung

dichloromethane

4-Methoxybenzenesulfonyl chloride

1-(2′,5′-difluoro-1,1′-biphenyl-2-yl)ethylamine

triethylamine

→

product

Ausbeute 89.2%

N-[1-(2′,5′-Difluoro-1,1′-biphenyl-2-yl)ethyl]-4-methoxybenzenesulfonamide

Ausbeute 89.2%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Waschenthe reaction washed with water
3. 3
   TrocknenThe organic phase was dried over anhydrous sodium sulfate
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated
6. 6
   Sonstigepurified by preparative liquid chromatography on a Biotage® 40 Mi column of prepacked silica gel (90 g)
7. 7
   Wascheneluting with a gradient of 30%-50% methyl tert-butyl ether in hexane (35 min)

Vorschrift

4-Methoxybenzenesulfonyl chloride (326 mg, 1.6 mmol) was added to a solution of 1-(2′,5′-difluoro-1,1′-biphenyl-2-yl)ethylamine (350 mg, 1.5 mmol) and triethylamine (418 uL, 3 mmol) in acetonitrile. The reaction was stirred at ambient temperature for 16 hours, whereupon dichloromethane was added and the reaction washed with water. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and purified by preparative liquid chromatography on a Biotage® 40 Mi column of prepacked silica gel (90 g), eluting with a gradient of 30%-50% methyl tert-butyl ether in hexane (35 min), to afford the product (540 mg, 89%) as a white solid, m.p. 143-144° C.;

Quelle