Reaktion #2267067

Reaktionsgleichung

3-methoxyphenylacetone

NaBH4

→

desired product 2

Ausbeute 100.0%

1-(3-Methoxyphenyl)-2-propyl alcohol

Ausbeute 100.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionIt was extracted with CHCl3 three times
2. 2
   WaschenThe combined organic phase was washed with brine
3. 3
   Trocknendried over Na2SO4
4. 4
   SonstigeRemoval of the solvent
5. 5
   Sonstigeafforded the crude product
6. 6
   SonstigePurification of the crude product

Vorschrift

To a solution of 3-methoxyphenylacetone (1, 1.0 g) in methanol (30 ml) was added NaBH4 (360 mg) in portions in the period of 20 min at 0° C. The resulting solution was stirred at such temperature for another 40 min. No more starting materials were detected from TLC. Ice water was added to the reaction slowly. It was extracted with CHCl3 three times. The combined organic phase was washed with brine, and dried over Na2SO4. Removal of the solvent afforded the crude product. Purification of the crude product by using a silica gel column gave the desired product 2 (1.01 g, 100%).

Quelle