Reaktion #2266577

Reaktionsgleichung

HCl

6-chloro-1-methyl-8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine

→

6-chloro-1-methyl-8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride

Ausbeute 184.1%

Lösungsmittel

methanol

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated in vacuo

Vorschrift

6-chloro-1-methyl-8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine (100 mg, 0.3 mmol) was converted to the hydrochloride salt by dissolving in methanol and treating with 1.25 M HCl in methanol. The reaction mixture was concentrated in vacuo to give 6-chloro-1-methyl-8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride (81a, 110 mg, 97%, AUC HPLC>99%): mp <<MP data>>; 1H NMR (DMSO-d6, 400 MHz) δ 9.55 (br s, 2H), 8.35 (d, J=1.6 Hz, 1H), 8.07-8.03 (m, 3H), 7.70-7.61 (m, 3H), 4.87-4.82 (m, 1H), 3.65-3.59 (m, 1H), 3.49-3.43 (m, 1H), 3.16-3.13 (m, 2H), 1.66 (d, J=6.8 Hz, 3H); ESI MS m/z 403 [M+H+CH3CN]+.

Quelle