Reaktion #2266562

Reaktionsgleichung

HCl

product

(8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-6-yl)methanol

→

(8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-6-yl)methanol hydrochloride

Lösungsmittel

dichloromethane

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated in vacuo

Vorschrift

The product obtained in step G (14 mg, 0.04 mmol) was converted to the hydrochloride salt by dissolving in dichloromethane and treating with 1.25 M HCl in methanol. The reaction mixture was concentrated in vacuo to give (8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridin-6-yl)methanol hydrochloride (15 mg, 97%, AUC HPLC>99%) as a white solid: mp <<MP data>>; 1H NMR (DMSO-d6, 400 MHz) δ 9.32 (br s, 2H), 8.30 (d, J=1.2 Hz, 1H), 7.99-7.87 (m, 3H), 7.71-7.57 (m, 3H), 5.58 (t, J=5.6 Hz, 1H), 4.81 (d, J=5.6 Hz, 2H), 4.38 (s, 2H), 3.52 (t, J=6.0 Hz, 2H), 3.17-3.05 (m, 2H); ESI MS m/z 344 [M+H]+.

Quelle