Reaktion #2264822

Reaktionsgleichung

product

1-(1-(4-fluorophenyl)-4,7-dimethyl-1H-[1,2,3]triazolo[4,5-c]pyridin-5(4H)-yl)-2-(4-methoxyphenyl)propan-2-ol

ammonium formate

→

title compound

Ausbeute 46.2%

1-(1-(4-fluorophenyl)-4,7-dimethyl-6,7-dihydro-1H-[1,2,3]triazolo[4,5-c]pyridin-5(4H)-yl)-2-(4-methoxyphenyl)propan-2-ol

Ausbeute 46.2%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction vessel was sealed
2. 2
   FiltrationThe reaction mixture was then filtered through Celite
3. 3
   Einengenconcentrated
4. 4
   Sonstigepurified on silica gel with 0-2% NH3 MeOH/CH2Cl2

Vorschrift

To a solution of the product of Example 238, Step 2 (200 mg, 0.49 mmol) in MeOH (2 mL) was added Pd/C (52 mg, 0.049 mmol) and ammonium formate (93 mg, 1.45 mmol). The reaction vessel was sealed and heated 80° C. for 16 h. The reaction mixture was then filtered through Celite, concentrated and purified on silica gel with 0-2% NH3 MeOH/CH2Cl2 to afford the title compound (93 mg, 46%). MS (ESI) mass calcd. C23H27FN4O2, 410.2. m/z found, 411.20 [M+H]+.

Quelle