Reaktion #2261592

ord-398184f8f5cc4f3dbd1ea42ed5ac0174

Reaktionsgleichung

C=C(C)[C@@H]1CC[C@@H](C)C[C@H]1O
1-isopulegol
[H][H]
hydrogen
→
CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
1-menthol
Ausbeute 93.8%

Edukte

C=C(C)[C@@H]1CC[C@@H](C)C[C@H]1O
1-isopulegol
[H][H]
hydrogen

Reagenzien

[Ni]
Raney nickel

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    FiltrationThe reaction mixture was filtered
  2. 2
    workup.DISTILLATIONfollowed by distillation

Vorschrift

In a 500-mL autoclave were added 100.0 g (0.65 mol) of the 1-isopulegol obtained in Example 44 and 0.4 g of Raney nickel in a nitrogen atmosphere. Hydrogenation was conducted at a hydrogen pressure of 2.5 MPa and 70° C. for 10 hours. The reaction mixture was filtered, followed by distillation to obtain 94.8 g (0.61 mol, 100% e.e.) of 1-menthol.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09061959B2uspto-grants-2015_06