Reaktion #2260430

Reaktionsgleichung

5-Fluoro-1-(hydroxymethyl)-2,3-dihydro-1H-indene-4-carbonitrile

Dess-MartinPeriodinane

N-Boc-piperazine

Sodium Cyanoborohydride

Na2S2O3

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title material

5-Fluoro-1-(piperazin-1-ylmethyl)-2,3-dihydro-1H-indene-4-carbonitrile

Lösungsmittel

DCM

DCM

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe mixture was extracted with DCM
2. 2
   Waschenthe DCM layer was washed with Na2CO3 and brine
3. 3
   Trocknendried over sodium sulfate
4. 4
   Einengenconcentrated
5. 5
   Sonstigereaction within 6 hours
6. 6
   SonstigeThe reductive amination adduct was then purified by MPLC
7. 7
   SonstigeFinally, the Boc group was removed
8. 8
   workup.ADDITIONby treating the carbamate with 4N HCl in dioxane
9. 9
   SonstigeAfter removal of solvent

Vorschrift

A solution of 5-Fluoro-1-(hydroxymethyl)-2,3-dihydro-1H-indene-4-carbonitrile (20 mg, 0.105 mmol) in DCM was treated with Dess-MartinPeriodinane (89 mg, 0.209 mmol) in DCM. When TLC showed the reaction was done, Na2S2O3 was added to the reaction. The solution was stirred vigorously until the two layers turned clear. The mixture was extracted with DCM, and the DCM layer was washed with Na2CO3 and brine, dried over sodium sulfate, and concentrated. The resulting oil was then treated with N-Boc-piperazine (39.0 mg, 0.209 mmol) and Sodium Cyanoborohydride (33 mg, 0.52 mmol) in DCM with a few drops of HOAc. LC showed complete reaction within 6 hours. The reductive amination adduct was then purified by MPLC. Finally, the Boc group was removed by treating the carbamate with 4N HCl in dioxane. After removal of solvent, the title material was obtained. LC-MS (IE, m/z): 260 [M+1]+.

Quelle