Reaktion #2260428

Reaktionsgleichung

5-Fluoro-1-(methoxymethylidene)-2,3-dihydro-1H-indene-4-carbonitrile

BBr3

→

5-Fluoro-1-formyl-2,3-dihydro-1H-indene-4-carbonitrile

Lösungsmittel

DCM

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with NaHCO3
2. 2
   Trocknendried over Na2SO4
3. 3
   Einengenconcentrated

Vorschrift

A solution of 5-Fluoro-1-(methoxymethylidene)-2,3-dihydro-1H-indene-4-carbonitrile (10 mg, 0.049 mmol) in DCM was cooled to −78° C. To this solution was dropped BBr3 (0.492 ml, 0.492 mmol). The mixture was allowed to stir for 15 minutes, and then it was diluted with DCM (10 mL), washed with NaHCO3, dried over Na2SO4, and concentrated. The residue was used directly in the next step.

Quelle