Reaktion #2259495

Reaktionsgleichung

(n-tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester

1-bromo-2-iodo-4-(trifluoromethyl)benzene

potassium phosphate

Isoquinolin-5-ylboronic acid

→

tert-butyl 4-(2-(isoquinolin-5-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Ausbeute 76.2%

Lösungsmittel

dioxane

water

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige3 hours
2. 2
   Sonstigeconsumption of starting material
3. 3
   Temperaturto cool to room temperature
4. 4
   WaschenThe organics were washed with water
5. 5
   Trocknenbrine, dried over MgSO4
6. 6
   Einengenconcentrated
7. 7
   SonstigePurification of the resulting residue by silica gel column chromatography (0 to 100% EtOAc/heptane)

Vorschrift

A solution of Cl2Pd(dppf)-CH2Cl2 adduct (Strem Chemicals Inc., Newburyport, Mass., 1.157 g, 1.416 mmol), (n-tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester (8.76 ml, 28.3 mmol), 1-bromo-2-iodo-4-(trifluoromethyl)benzene (9.94 g, 28.3 mmol), and potassium phosphate (36.1 g, 170 mmol) in 100 mL dioxane, 40 mL water was heated to 100° C. 3 hours. LC/MS showed complete consumption of starting material. Isoquinolin-5-ylboronic acid (4.90 g, 28.3 mmol) and Cl2Pd(AmPhos) (Sigma-Aldrich, St. Louis, Mo., 1.003 g, 1.416 mmol) were added, and the reaction mixture was again heated to 100° C. for an additional hour. The reaction mixture was allowed to cool to room temperature and was diluted with diethyl ether. The organics were washed with water, then brine, dried over MgSO4 and concentrated. Purification of the resulting residue by silica gel column chromatography (0 to 100% EtOAc/heptane) gave tert-butyl 4-(2-(isoquinolin-5-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate (9.80 g, 21.56 mmol).

Quelle