Reaktion #2256932

Reaktionsgleichung

2-[4-(6-Benzyloxyhexanoylamino)phenoxy]propionic acid methyl ester

→

79

Ausbeute 51.6%

2-[4-(6-Hydroxyhexanoylamino)phenoxy]propionic acid methyl ester

Ausbeute 51.6%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeCatalyst was removed by filtration and methanol
2. 2
   workup.DISTILLATIONdistilled off
3. 3
   SonstigeThe crude 79 was purified by column chromatography on silica gel

Vorschrift

2-[4-(6-Benzyloxyhexanoylamino)phenoxy]propionic acid methyl ester 78 (15 g, 37.59 mmol) was dissolved in methanol (150 ml) in a pressure vessel, palladium on carbon (50% wet, 5%, 15 g) added and the mixture stirred under a hydrogen atmosph. (4 Kg) for 16 hrs. Catalyst was removed by filtration and methanol distilled off. The crude 79 was purified by column chromatography on silica gel using chloroform as eluant to get pure 79 (6 g, 51.6%) as a white powder. M.p: 62-64.5° C.

Quelle