Reaktion #2254455

ord-5e7c72f0817f4542bca04c2dd8108ba8

Reaktionsgleichung

CC(=O)N1c2ccc(C(=O)O)cc2C(Nc2ccc(Cl)cc2)C[C@@H]1C
(2S)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinoline-6-carboxylic acid
CC(C)(C)OC(=O)CCOCCOCCOCCN
tert-butyl 12-amino-4,7,10-trioxadodecanoate
→
CC(=O)N1c2ccc(C(=O)NCCOCCOCCOCCC(=O)OC(C)(C)C)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C
title compound
Ausbeute 102.1%
CC(=O)N1c2ccc(C(=O)NCCOCCOCCOCCC(=O)OC(C)(C)C)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C
tert-butyl 12-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinoline-6-carboxamido}-4,7,10-trioxadodecanoate
Ausbeute 102.1%

Edukte

CC(=O)N1c2ccc(C(=O)O)cc2C(Nc2ccc(Cl)cc2)C[C@@H]1C
(2S)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinoline-6-carboxylic acid
CC(C)(C)OC(=O)CCOCCOCCOCCN
tert-butyl 12-amino-4,7,10-trioxadodecanoate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Reactions and treatments were carried out in the same manner as in Example 110, using 29 mg of (2S)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinoline-6-carboxylic acid and 44 mg of tert-butyl 12-amino-4,7,10-trioxadodecanoate. Thus, 51 mg (100%) of the title compound was obtained as a colorless oily substance.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09045423B2uspto-grants-2015_06