Reaktion #2254331

Reaktionsgleichung

n-BuLi

1,3-dichloro-5-(trifluoromethyl)benzene

DMF

→

title compound

2,6-dichloro-4-(trifluoromethyl)benzaldehyde

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigequenched with NH4Cl solution
2. 2
   Extraktionextracted with diethyl ether
3. 3
   TrocknenThe combined extracts were dried (Na2SO4)
4. 4
   Einengenconcentrated
5. 5
   Sonstigepurified via column chromatography

Vorschrift

A 2M n-BuLi solution (5.8 mL, 11.6 mmol) was added to a −78° C. THF solution (60 mL) of 1,3-dichloro-5-(trifluoromethyl)benzene (2.5 g, 11.6 mmol). After 45 min neat DMF (0.39 mL, 5.0 mmol) was added, and the resulting solution was allowed to warm to 0° C. gradually, quenched with NH4Cl solution, and extracted with diethyl ether. The combined extracts were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.

Quelle