Reaktion #2254199

ord-209d9e9339364d4db7de1f3c96ee0a96

Reaktionsgleichung

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
Apomorphine hydrochloride
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride
→
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
Apomorphine

Edukte

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
Apomorphine hydrochloride
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONmixed thoroughly (i.e.
  2. 2
    workup.STIRRINGthe mixture was again homogenized
  3. 3
    workup.ADDITIONby addition of a suitable acid
  4. 4
    workup.ADDITIONThe solution is then poured onto a sheet
  5. 5
    Sonstigedried in a heated oven

Vorschrift

Gelatin and mannitol are dispersed in purified water and mixed thoroughly (i.e., using a vacuum mixer) and homogenized. Apomorphine hydrochloride is added and the mixture was again homogenized to ensure complete dissolution of the apomorphine hydrochloride. The pH of the solution is adjusted to about 3.0 (i.e., by addition of a suitable acid, such as citric acid). The solution is then poured onto a sheet and dried in a heated oven.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09044475B2uspto-grants-2015_06