Reaktion #2254170

Reaktionsgleichung

2-Ethoxycarbonyl-7-hydroxychromone

sodium carbonate

HCl

→

7-hydroxy-4-oxo-4H-chromone-2-carboxylic acid

Lösungsmittel

ethanol

H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONis added dropwise
2. 2
   TemperaturAfter cooling
3. 3
   FiltrationThe precipitated white solid is filtered off with suction
4. 4
   Waschenwashed until neutral and
5. 5
   Sonstigedried

Vorschrift

2-Ethoxycarbonyl-7-hydroxychromone (14.5 g, 62 mmol) is initially introduced dissolved in ethanol (400 ml) at 50° C., and sodium carbonate (20 g, 190 mmol) dissolved in deionised H2O (200 ml) is added dropwise. The mixture is refluxed at 80° C. for 3 hours with stirring. After cooling, the mixture is acidified using 2N HCl. The precipitated white solid is filtered off with suction, washed until neutral and dried.

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