Reaktion #2253883

Reaktionsgleichung

2-(5-dimethylaminomethyl-2-thienylmethylthio)ethylamine

2-nitroamino-5-(5-dimethylaminomethyl-2-thienylmethyl)-4-pyrimidone

→

2-(5-dimethylaminomethyl-2-thienylmethylthio)ethylamino-5-(5-dimethylaminomethyl-2-thienylmethyl)-4-pyrimidone

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe pyridine was removed under reduced pressure
2. 2
   Sonstigethe last traces of pyridine were removed
3. 3
   Sonstigeby azeotroping with water

Vorschrift

A solution of 2-(5-dimethylaminomethyl-2-thienylmethylthio)ethylamine (1.47 g) and 2-nitroamino-5-(5-dimethylaminomethyl-2-thienylmethyl)-4-pyrimidone (2.0 g) in pyridine (10 ml) was refluxed overnight. The pyridine was removed under reduced pressure and the last traces of pyridine were removed by azeotroping with water yielding 2-(5-dimethylaminomethyl-2-thienylmethylthio)ethylamino-5-(5-dimethylaminomethyl-2-thienylmethyl)-4-pyrimidone as an oil. The resultant oil was washed by decantation with water.

Quelle