Reaktion #2251387

Reaktionsgleichung

acetic acid

2,2-dimethyl-1,3-benzodioxole-4-sulfonamide

trimethylaluminum

methyl [4-methoxy-6-methyl-1,3,5-triazin-2-yl]carbamate

→

white solid

Ausbeute 7.2%

N-[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2,2-dimethyl-1,3-benzodioxole-4-sulfonamide

Ausbeute 7.2%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Temperaturthe reaction mixture was heated
3. 3
   Temperaturat reflux 72 hours
4. 4
   TemperaturThe reaction mixture was cooled to room temperature
5. 5
   SonstigeThe organic phase was separated
6. 6
   Sonstigedried
7. 7
   Sonstigethe solvent removed under reduced pressure
8. 8
   Sonstigeto give an oil
9. 9
   SonstigeCrystallization of the oil
10. 10
    workup.ADDITIONfrom a mixture of ether, methylene chloride, and hexane

Vorschrift

To a solution of 1.0 g 2,2-dimethyl-1,3-benzodioxole-4-sulfonamide, prepared in Example 1, in 50 ml methylene chloride a room temperature under nitrogen was added 2.5 ml trimethylaluminum (2M in toluene). After stirring 15 minutes at room temperature, 0.7 g of methyl [4-methoxy-6-methyl-1,3,5-triazin-2-yl]carbamate, prepared according to the procedure of Example 5, was added and the reaction mixture was heated at reflux 72 hours. The reaction mixture was cooled to room temperature and 75 ml ice, 3 ml glacial acetic acid, and 10 drops of hydrochloric acid were sequentially added. The organic phase was separated, dried and the solvent removed under reduced pressure to give an oil. Crystallization of the oil from a mixture of ether, methylene chloride, and hexane gave 0.1 g of white solid, m.p. 160°-168° C. The infrared spectrum showed a carbonyl absorption at 1705 cm-1 indicative of the title compound.

Quelle