Reaktion #2251365

Reaktionsgleichung

sodium hydroxide

6-methyl-5-octen-2-one

sodium borohydride

methanol

→

6-methyl-5-octen-2-ol

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto destroy excess sodium borohydride
2. 2
   workup.ADDITIONthe solution poured into water
3. 3
   Extraktionextracted with ether
4. 4
   WaschenThe combined ether extracts are washed with aqueous sodium bicarbonate, water and brine
5. 5
   Sonstigedried
6. 6
   Sonstigeevaporated

Vorschrift

Six grams of 6-methyl-5-octen-2-one is added to a solution of 3.0 g. of sodium borohydride, 80 ml. of methanol and 6 ml. of 2N sodium hydroxide solution. After about two hours, acetic acid is added to destroy excess sodium borohydride and the solution poured into water and extracted with ether. The combined ether extracts are washed with aqueous sodium bicarbonate, water and brine, dried and evaporated to yield 6-methyl-5-octen-2-ol which is purified by chromatography.

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