Reaktion #2245

Reaktionsgleichung

3-(4-pyridinylamino)-1,2-benzisoxazole

methyl bromoacetate

→

title compound

Ausbeute 70.0%

[4-(3-Benzo[d]isoxazolylimino)-1-(4H)-pyridinyl]-acetic acid methyl ester hydrobromide

Ausbeute 70.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturat reflux for one hour
3. 3
   Filtrationthe precipitated product was collected by filtration
4. 4
   WaschenThe white solid was washed with diethyl ether
5. 5
   Sonstigedried under vacuum

Vorschrift

A mixture of 3-(4-pyridinylamino)-1,2-benzisoxazole (0.9 g, 4.3 mmol) and methyl bromoacetate (0.44 mL, 1.1 eq) in acetonitrile (25 mL) was heated at reflux for one hour. The mixture was then allowed to cool to room temperature and the precipitated product was collected by filtration. The white solid was washed with diethyl ether and dried under vacuum to provide the title compound (1.1 g, 70%), mp 235-236° C.

Quelle