Reaktion #2239

Reaktionsgleichung

N-(3-hydroxy-4-methoxybenzenesulphonyl)- 1,2-dihydroindole

3-phenoxypropylbromide

cesium carbonate

→

title compound

Ausbeute 86.8%

N-[3-(Phenoxypropoxy)-4-methoxybenzenesulphonyl]-1,2-dihydroindole

Ausbeute 86.8%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed in vacuo
2. 2
   Sonstigethe residue partitioned between dichloromethane (30 ml) and water (15 ml)
3. 3
   WaschenThe organic phase was washed with brine (15 ml)
4. 4
   Trocknenthen dried over magnesium sulphate
5. 5
   Einengenconcentrated in vacuo
6. 6
   SonstigeThe residue was purified
7. 7
   Wascheneluting with dichloromethane

Vorschrift

A solution of N-(3-hydroxy-4-methoxybenzenesulphonyl)- 1,2-dihydroindole (0.2 g) and 3-phenoxypropylbromide (0.15 g) in N,N-dimethylformamide (20 ml) was treated with cesium carbonate (0.3 g) and heated at 75° C. overnight. The solvent was removed in vacuo and the residue partitioned between dichloromethane (30 ml) and water (15 ml). The organic phase was washed with brine (15 ml) then dried over magnesium sulphate and concentrated in vacuo. The residue was purified using column chromatography eluting with dichloromethane to yield the title compound as a white solid (0.25 g).

Quelle