Reaktion #2224

Reaktionsgleichung

2-bromo-p-chloroacetophenone

methoxythiocarbonylhydrazine

→

5-(4-chlorophenyl)-3H,6H-1,3,4-thiadiazin-2-one

Ausbeute 48.4%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed overnight
2. 2
   Temperaturcooled
3. 3
   Filtrationfiltered
4. 4
   WaschenThe light yellow solid was washed with hexane
5. 5
   Sonstigedried

Vorschrift

A mixture of 2-bromo-p-chloroacetophenone (9.16 g), methoxythiocarbonylhydrazine (13.0 g) and acetonitrile (75 ml) was refluxed overnight and then cooled and filtered. The light yellow solid was washed with hexane and dried yielding 5-(4-chlorophenyl)-3H,6H-1,3,4-thiadiazin-2-one (4.3 g).

Quelle