Reaktion #2205943

Reaktionsgleichung

2-tert-butyl-5-[4-methylpiperidin-1-yl]-6-nitrobenzothiazole

→

6-amino-2-tert-butyl-5-[4-methylpiperidin-1-yl]benzothiazole

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter removing the catalyst the solution
2. 2
   Einengenis concentrated
3. 3
   Filtrationthe solid filtered

Vorschrift

A solution of 15.2 g of 2-tert-butyl-5-[4-methylpiperidin-1-yl]-6-nitrobenzothiazole in 600 ml of methanol is hydrogenated in presence of 6.5 g of raney nickel at room temperature. After removing the catalyst the solution is concentrated and the solid filtered to give 6-amino-2-tert-butyl-5-[4-methylpiperidin-1-yl]benzothiazole melting at 146°-148°.

Quelle