Reaktion #220470

ord-b16250ec11b841ed8e5499c6702fffbc

Reaktionsgleichung

O=C(O)CC1CCCC1
cyclopentylacetic acid
CC(C)CN1C(=O)C(NC(=O)[C@H](C)N)C(=O)N(CC(C)C)c2ccccc21.Cl
3-(L-alaninyl)amino-2,4-dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine hydrochloride
→
CC(C)CN1C(=O)C(NC(=O)[C@H](C)NC(=O)CC2CCCC2)C(=O)N(CC(C)C)c2ccccc21
title compound
CC(C)CN1C(=O)C(NC(=O)[C@H](C)NC(=O)CC2CCCC2)C(=O)N(CC(C)C)c2ccccc21
3-[N′-(Cyclopentylacetyl)-L-alaninyl]amino-2,4-dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Edukte

O=C(O)CC1CCCC1
cyclopentylacetic acid
CC(C)CN1C(=O)C(NC(=O)[C@H](C)N)C(=O)N(CC(C)C)c2ccccc21.Cl
3-(L-alaninyl)amino-2,4-dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePurification
  2. 2
    Wascheneluting with CH2Cl2/EtOAc (1:1)

Vorschrift

Following General Procedure I above using cyclopentylacetic acid (Aldrich) and 3-(L-alaninyl)amino-2,4-dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine hydrochloride (Example 8-S), the title compound was prepared as an amorphous white solid. Purification was by flash chromatography eluting with CH2Cl2/EtOAc (1:1). Rf=0.31 (CH2Cl2/EtOAc, 1:1).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07390801B2uspto-grants-2008_06