Reaktion #2201693

Reaktionsgleichung

3-bromo-10-piperidin-4-yl-10H-phenothiazine

5e

3-Bromo-10-piperidin-4-yl-10H-phenothiazine

4-pyridyl boronic acid

3-pyridyl boronic acid

2i

4-(3-Chloro-phenoxazin-10-yl)-piperidine-1-carboxylic acid tert-butyl ester

→

1k

4-(3-Pyridin-4-yl-phenoxazin-10-yl)-piperidine-1-carboxylic acid tert-butyl ester

Lösungsmittel

dioxane

NMP

water

Reaktionsbedingungen

Vorschrift

Using an adaptation of the method described in Procedure 16, substituting 4-(3-chloro-phenoxazin-10-yl)-piperidine-1-carboxylic acid tert-butyl ester, 2i, for 3-bromo-10-piperidin-4-yl-10H-phenothiazine, 5e, 4-pyridyl boronic acid for 3-pyridyl boronic acid, Cp2Fe(PtBu2)2PdCl2 for Pd(PPh3)4 and a 5:1 mixture of dioxane:water for NMP, the title compound 4-(3-pyridin-4-yl-phenoxazin-10-yl)-piperidine-1-carboxylic acid tert-butyl ester, 1k was obtained. MS m/z (MH+) 444.

Quelle