Reaktion #2200341

ord-0c9b1cdfdc764fbb8e30af6667541ae8

Reaktionsgleichung

CCC1(C(=O)OC)Cc2cc(O)ccc2O1
phenol
CCC1(C(=O)OC)Cc2cc(O)ccc2O1
2-Ethyl-5-hydroxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
CC(C)(C)Cc1ccc(OCCCI)c(Cl)c1
iodide
CC(C)(C)Cc1ccc(OCCCI)c(Cl)c1
2-chloro-1-(3-iodo-propoxy)-4-(2,2-dimethylpropyl)-benzene
→
CC[C@@]1(C(=O)O)Cc2cc(OCCCOc3ccc(CC(C)(C)C)cc3Cl)ccc2O1
title compound
CC[C@@]1(C(=O)O)Cc2cc(OCCCOc3ccc(CC(C)(C)C)cc3Cl)ccc2O1
(2S)-5-{3-[2-Chloro-4-(2,2-dimethyl-propyl)-phenoxy]-propoxy}-2-ethyl-2,3-dihydro-benzofuran-2-carboxylic acid

Edukte

CCC1(C(=O)OC)Cc2cc(O)ccc2O1
phenol
CCC1(C(=O)OC)Cc2cc(O)ccc2O1
2-Ethyl-5-hydroxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester
CC(C)(C)Cc1ccc(OCCCI)c(Cl)c1
iodide
CC(C)(C)Cc1ccc(OCCCI)c(Cl)c1
2-chloro-1-(3-iodo-propoxy)-4-(2,2-dimethylpropyl)-benzene

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared following the general procedure described in Example 1, Step 4 employing the chiral phenol prepared in Example 10, Step 2 and the iodide prepared in Step 1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07524882B2uspto-grants-2009_04