Reaktion #2199714
ord-fc18d0116d304004b0bd71f66b3c00c5
Reaktionsgleichung
diisobutylaluminum hydride
(2-amino-4-fluoro-5-methoxyphenyl)-(2-chlorophenyl)-methanone
4-amino-5-chloro-3-methyl-1-(2-propenyl)-1 H-pyrazole
4-amino-5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole
5-(2-chlorophenyl)-1,2-dihydro-8-fluoro-7-methoxy-3-methyl-1-(2-propenyl)-pyrazolo[3,4-b][1,4]benzodiazepine
→
Edukte
diisobutylaluminum hydride
(2-amino-4-fluoro-5-methoxyphenyl)-(2-chlorophenyl)-methanone
4-amino-5-chloro-3-methyl-1-(2-propenyl)-1 H-pyrazole
4-amino-5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole
5-(2-chlorophenyl)-1,2-dihydro-8-fluoro-7-methoxy-3-methyl-1-(2-propenyl)-pyrazolo[3,4-b][1,4]benzodiazepine
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
5-(2-chlorophenyl)-1,2-dihydro-8-fluoro-7-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVdd) was prepared by reacting 0.0023 moles of (2-amino-4-fluoro-5-methoxyphenyl)-(2-chlorophenyl)-methanone (Xdd) with 4-amino-5-chloro-3-methyl-1-(2-propenyl)-1 H-pyrazole (XIII), and subsequent dealkylation of the intermediate, 5-(2-chlorophenyl)-1,2-dihydro-8-fluoro-7-methoxy-3-methyl-1-(2-propenyl)-pyrazolo[3,4-b][1,4]benzodiazepine (XIVdd) with diisobutylaluminum hydride in a manner analogous to Example 72. MH+/Z=357.