Reaktion #2199713

Reaktionsgleichung

diisobutylaluminum hydride

(2-amino-5-chloro-4-methoxyphenyl)-(2-chlorophenyl)-methanone

4-amino-5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole

7-chloro-5-(2-chlorophenyl)-1,2-dihydro-8-methoxy-3-methyl-1-(2-propenyl)-pyrazolo[3,4-b][1,4]benzodiazepine

→

7-chloro-5-(2-chlorophenyl)-1,2-dihydro-8-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine

Reaktionsbedingungen

Vorschrift

7-chloro-5-(2-chlorophenyl)-1,2-dihydro-8-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVcc) was prepared by reacting 0.0023 moles of (2-amino-5-chloro-4-methoxyphenyl)-(2-chlorophenyl)-methanone (Xcc) with 4-amino-5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole (XIII), and subsequent dealkylation of the intermediate, 7-chloro-5-(2-chlorophenyl)-1,2-dihydro-8-methoxy-3-methyl-1-(2-propenyl)-pyrazolo[3,4-b][1,4]benzodiazepine (XIVcc) with diisobutylaluminum hydride in a manner analogous to Example 72. MH+/Z=373.

Quelle