Reaktion #2199712

Reaktionsgleichung

diisobutylaluminum hydride

(2-amino-4,5-dimethoxyphenyl)-(2-methoxyphenyl)-methanone

4-amino-5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole

1,2-dihydro-7,8-dimethoxy-5-(2-methoxyphenyl)-3-methyl-1-(2-propenyl)-pyrazolo[3,4-b][1,4]benzodiazepine

→

1,2-dihydro-7,8-dimethoxy-5-(2-methoxyphenyl)-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine

Reaktionsbedingungen

Vorschrift

1,2-dihydro-7,8-dimethoxy-5-(2-methoxyphenyl)-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVaa) was prepared by reacting 0.0023 moles of (2-amino-4,5-dimethoxyphenyl)-(2-methoxyphenyl)-methanone (Xaa) with 4-amino-5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole (XIII), and subsequent dealkylation of the intermediate, 1,2-dihydro-7,8-dimethoxy-5-(2-methoxyphenyl)-3-methyl-1-(2-propenyl)-pyrazolo[3,4-b][1,4]benzodiazepine (XIVaa) with diisobutylaluminum hydride in a manner analogous to Example 72. MH+/Z=365.

Quelle