Reaktion #2195473

ord-043dc0a2b807409b8a6633c7a76e8f91

Reaktionsgleichung

Oc1ccccc1
phenol
[H-].[Na+]
sodium hydride
Cl
HCl
→
c1ccc2c(c1)oc1ccccc12
Dibenzofuran

Edukte

Oc1ccccc1
phenol
[H-].[Na+]
sodium hydride
Cl
HCl

Reagenzien

Keine

Lösungsmittel

CS(C)=O
DMSO

Reaktionsbedingungen

Temperatur
120°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    ExtraktionThe aqueous phase is extracted with MTB ether
  2. 2
    TrocknenThe organic phase is dried over sodium sulfate
  3. 3
    Sonstigeevaporated
  4. 4
    Sonstigechromatographed on silica gel

Vorschrift

The phenol 10 is dissolved in DMSO under nitrogen, a 60% sodium hydride/mineral oil suspension is added, and the mixture is warmed to 120° C. After 5 hours at this temperature, the cooled batch is added to dil. HCl solution. The aqueous phase is extracted with MTB ether. The organic phase is dried over sodium sulfate, evaporated and chromatographed on silica gel.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07514127B2uspto-grants-2009_04