Reaktion #219536

Reaktionsgleichung

hydrochloric acid

tert-butyl 4-(1-hydroxy-3-methoxy-3-oxo-1-(2-pivalamidopyridin-3-yl)propan-2-yl)piperidine-1-carboxylate

→

Title compound

Ausbeute 33.0%

3-(Piperidin-4-yl)-1,8-naphthyridin-2(1H)-one dihydrochloride

Ausbeute 33.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeReaction
2. 2
   Temperaturwas heated
3. 3
   Temperaturto reflux
4. 4
   EinengenMixture was concentrated in vacuo
5. 5
   SonstigeResidue was crystallized from ethanol

Vorschrift

Concentrated hydrochloric acid (25 mL, 305 mmol) was added with stirring to a mixture of tert-butyl 4-(1-hydroxy-3-methoxy-3-oxo-1-(2-pivalamidopyridin-3-yl)propan-2-yl)piperidine-1-carboxylate (14.0 g, 30.2 mmol) and water (75 mL). Reaction was heated to reflux and held for 25 hours. Mixture was concentrated in vacuo. Residue was crystallized from ethanol. Title compound was obtained as white solid in 33% yield. (M+H)+=230.2.

Quelle