Reaktion #2195219

Reaktionsgleichung

2-[2-[(4-bromobutyl)oxy]ethyl]pyridine

2,4-pentanedione

potassium carbonate

potassium iodide

→

oil

Ausbeute 83.3%

7-[2-(2-Pyridinyl)ethoxy]-2-heptanone

Ausbeute 83.3%

Lösungsmittel

ether

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated overnight
2. 2
   Temperaturunder reflux
3. 3
   SonstigeThe solids were removed by filtration
4. 4
   Sonstigethe filtrate evaporated
5. 5
   Sonstigeto leave a dark brown semi-solid
6. 6
   Sonstigeproduced a brown solution which
7. 7
   Sonstigewas evaporated

Vorschrift

A mixture of 2-[2-[(4-bromobutyl)oxy]ethyl]pyridine (6.2 g), 2,4-pentanedione (3.61 g), potassium carbonate (4.75 g) and potassium iodide (3.95 g) in ethanol (125 ml) was stirred and heated overnight under reflux. The solids were removed by filtration and the filtrate evaporated to leave a dark brown semi-solid. Addition of ether (200 ml) and filtration of the solid produced a brown solution which was evaporated to give a brown oil (4.71 g). Purification by FCC eluting with ether-hexane (1:1→3:1) gave the title compound as a pale yellow oil (1.93 g).

Quelle