Reaktion #219402

Reaktionsgleichung

hydrochloric acid

tert-butyl 4-(1-hydroxy-3-methoxy-3-oxo-1-(4-pivalamidopyridin-3-yl)propan-2-yl)piperidine-1-carboxylate

→

Title compound

Ausbeute 77.0%

3-(piperidin-4-yl)-1,6-naphthyridin-2(1H)-one

Ausbeute 77.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeReaction
2. 2
   Temperaturwas heated
3. 3
   Temperaturto reflux
4. 4
   EinengenMixture was concentrated in vacuo
5. 5
   workup.ADDITIONResidue was treated with acetonitrile (70 mL)
6. 6
   Einengenconcentrated in vacuo
7. 7
   SonstigeResidue was crystallized from ethanol

Vorschrift

Concentrated hydrochloric acid (8.0 mL, 97 mmol) was added with stirring to a mixture of tert-butyl 4-(1-hydroxy-3-methoxy-3-oxo-1-(4-pivalamidopyridin-3-yl)propan-2-yl)piperidine-1-carboxylate (1.2 g, 2.6 mmol) and water (24 mL). Reaction was heated to reflux and held for 14 hours. Mixture was concentrated in vacuo. Residue was treated with acetonitrile (70 mL) and then concentrated in vacuo. Residue was crystallized from ethanol. Title compound was obtained as white solid in 77% yield. (M+H)+=230.1.

Quelle