Reaktion #219399

Reaktionsgleichung

pivaloyl chloride

Triethlyamine

2-aminopyridine-3-carboxaldehyde

→

title compound

Ausbeute 90.0%

N-(3-Formylpyridin-2-yl)pivalamide

Ausbeute 90.0%

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeReaction
2. 2
   Temperaturwas warmed to room temperature
3. 3
   WaschenMixture was washed successively with water (2×50 mL) and brine (30 mL)
4. 4
   TrocknenOrganic layer was dried (magnesium sulfate)
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated in vacuo

Vorschrift

Triethlyamine (7.6 mL, 54 mmol), was added to a solution of 2-aminopyridine-3-carboxaldehyde (4.45 g, 36 mmol) in dichloromethane (70 mL). Mixture was cooled to 0° C. A solution of pivaloyl chloride (5.3 mL, 43 mmol) in dichloromethane (30 mL) was added to the mixture. Reaction was warmed to room temperature. Mixture stirred at room temperature for 63 hours. Mixture was washed successively with water (2×50 mL) and brine (30 mL). Organic layer was dried (magnesium sulfate), filtered and concentrated in vacuo. Silica gel chromatography afforded the title compound as off-white solid in 90% yield. (M+H)+=207.1.

Quelle