Reaktion #2192271

Reaktionsgleichung

Intermediate 448.2

5-ethyl-2-fluoro-3-(hydroxy(4-phenyl-1-trityl-1H-imidazol-2-yl)methyl)phenol

K2CO3

iodoethane

→

Intermediate 448.3

Ausbeute 100.1%

(3-ethoxy-5-ethyl-2-fluorophenyl)(4-phenyl-1-trityl-1H-imidazol-2-yl)methanol

Ausbeute 100.1%

Lösungsmittel

DMF

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe organic phase was washed with H2O (2×), sat. Na2SO3 and brine
2. 2
   Trocknendried (Na2SO4)
3. 3
   Filtrationfiltered through 1″ SiO2
4. 4
   Einengenconcentrated

Vorschrift

To a solution of Intermediate 448.2 (1.00 g, 1.80 mmol) in 10 mL DMF at rt, were added K2CO3 (229 mg, 2.16 mmol) and iodoethane (432 μL, 5.4 mmol). The mixture was stirred at rt for 19 h, then diluted with EtOAc. The organic phase was washed with H2O (2×), sat. Na2SO3 and brine, dried (Na2SO4), filtered through 1″ SiO2 and concentrated to afford 1.05 g of Intermediate 448.3 as a colorless solid. LCMS (2 min gradient) RT=1.92 min, 583.3 (M+H)+.

Quelle