Reaktion #2192203
ord-250436819805498dadd6652d7401cba2
Reaktionsgleichung
chloro
4-bromo-2-(chloro(5-ethyl-2-fluoro-3-methoxyphenyl)methyl)-1-trityl-1H-imidazole
Intermediate 206.4
di-tert-butyl (6-{[(4-bromo-1-trityl-1H-imidazol-2-yl)(5-ethyl-2-fluoro-3-methoxyphenyl)methyl]amino}isoquinolin-1-yl)imidodicarbonate
Intermediate 213.1
(4-bromo-1-trityl-1H-imidazol-2-yl)(3-ethoxy-5-ethyl-2-fluorophenyl)methanol
di-tert-butyl (6-aminoisoquinolin-1-yl)imidodicarbonate
→
Edukte
chloro
4-bromo-2-(chloro(5-ethyl-2-fluoro-3-methoxyphenyl)methyl)-1-trityl-1H-imidazole
Intermediate 206.4
di-tert-butyl (6-{[(4-bromo-1-trityl-1H-imidazol-2-yl)(5-ethyl-2-fluoro-3-methoxyphenyl)methyl]amino}isoquinolin-1-yl)imidodicarbonate
Intermediate 213.1
(4-bromo-1-trityl-1H-imidazol-2-yl)(3-ethoxy-5-ethyl-2-fluorophenyl)methanol
di-tert-butyl (6-aminoisoquinolin-1-yl)imidodicarbonate
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
According to the procedure for the preparation of Intermediate 206.4, Intermediate 213.1 (1.02 g, 1.74 mmol) was converted to the chloro intermediate, which was displaced with di-tert-butyl (6-aminoisoquinolin-1-yl)imidodicarbonate (688 mg, 1.91 mmol) to afford after flash chromatography (0 to 60% EtOAc/hexanes gradient) 1.47 g of Intermediate 213.2 as a pale yellow solid.