Reaktion #219220

Reaktionsgleichung

pyran

3,4-dihydro-2H-pyran

p-toluenesulphonic acid monohydrate

4-nitro-1H-pyrazole-3-carboxylic acid 4-hydroxy-cyclohexylamide

→

tetrahydro-pyran-2-yl-1H-pyrazole-3-carboxylic acid [4-(tetrahydro-pyran-2-yloxy)-cyclohexyl]-amide

Lösungsmittel

CH2Cl2

chloroform

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigereaction to completion
2. 2
   Waschenwashed successively with saturated aqueous sodium bicarbonate, water and brine
3. 3
   Wascheneluting with hexane (2 column lengths)

Vorschrift

A solution of 4-nitro-1H-pyrazole-3-carboxylic acid 4-hydroxy-cyclohexylamide (1.95 g; 7.67 mmol) in a mix of THF (50 ml) and chloroform (100 ml), was treated with 3,4-dihydro-2H-pyran (1.54 ml, 15.34 mmol) and p-toluenesulphonic acid monohydrate (100 mg). The reaction mixture was stirred at room temperature overnight, and then excess pyran (0.9 ml) was added in total to bring reaction to completion. The reaction mixture was diluted with CH2Cl2 and washed successively with saturated aqueous sodium bicarbonate, water and brine. The resulting solution was reduced in vacuo and subject to Biotage column chromatography, eluting with hexane (2 column lengths) followed by 30% ethyl acetate: hexane (10 column lengths), 70% ethyl acetate: hexane (10 column lengths) to give 1.25 g of 4-nitro-1-(tetrahydro-pyran-2-yl-1H-pyrazole-3-carboxylic acid [4-(tetrahydro-pyran-2-yloxy)-cyclohexyl]-amide. (LC/MS: Rt 2.97, [M+H]+423).

Quelle