Reaktion #2192187

Reaktionsgleichung

4,6-dimethyl-2-nitroaniline

→

Intermediate 179.1

Ausbeute 109.5%

3,5-dimethylbenzene-1,2-diamine

Ausbeute 109.5%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture evacuated
2. 2
   Sonstigeflushed with H2 (3×)
3. 3
   workup.ADDITIONConc. HCl (2 drops) was added
4. 4
   workup.STIRRINGthe mixture was stirred under H2 for an additional 18 h
5. 5
   Filtrationwas filtered
6. 6
   Einengenconcentrated

Vorschrift

To a solution of 4,6-dimethyl-2-nitroaniline (312 mg) in 5 mL MeOH, was added 10% Pd/C (50 mg). The mixture evacuated and flushed with H2 (3×), then was stirred under an atmosphere of H2 for 6 h. Conc. HCl (2 drops) was added and the mixture was stirred under H2 for an additional 18 h, then was filtered and concentrated to afford 280 mg of Intermediate 179.1, which was used without further purification.

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