Reaktion #2192

Reaktionsgleichung

4-bromomethyl-4'-chlorobenzophenone

sodium methanesulfinate

N,N-dimethylformamide

→

desired product

Ausbeute 90.6%

4-Chloro-4'-methylsulfonylmethyl-benzophenone

Ausbeute 90.6%

Lösungsmittel

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe mixture was extracted with ethyl acetate
2. 2
   WaschenThe ethyl acetate layer was washed with water
3. 3
   Trocknendried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONEthyl acetate was distilled off under reduced pressure
5. 5
   WaschenThe residual solid was washed with n-hexane

Vorschrift

4-bromomethyl-4'-chlorobenzophenone (3.1 g) and sodium methanesulfinate (1.5 g) were added to N,N-dimethylformamide (50 ml), and the mixture was stirred for 16 hours at room temperature. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residual solid was washed with n-hexane to obtain the desired product (2.8 g, melting point: 164° to 166° C., yield: 90%).

Quelle