Reaktion #219142

Reaktionsgleichung

5-formyl-2-(2-methylpropoxy)-aniline

2-methyl-propanol

4-fluoro-3-nitrobenzaldehyde

5-formyl-2-(2-methylpropoxy)aniline

2-aminothiazole

→

4-(2-Methylpropoxy)-3-nitrobenzaldehyde

Ausbeute 75.0%

1-(5-Formyl-2-isobutoxy-phenyl)-3-thiazol-2-yl-urea

Ausbeute 65.0%

Reaktionsbedingungen

Vorschrift

4-(2-Methylpropoxy)-3-nitrobenzaldehyde (0.83 g, 75%) was prepared from 2-methyl-propanol (0.46 ml, 5.0 mmol) and 4-fluoro-3-nitrobenzaldehyde (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 5-formyl-2-(2-methylpropoxy)-aniline (0.49 g, 68%) following general procedure B. 1-(5-Formyl-2-isobutoxy-phenyl)-3-thiazol-2-yl-urea (208 mg, 65%) was prepared from 5-formyl-2-(2-methylpropoxy)aniline (193 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.

Quelle