Reaktion #219132

Reaktionsgleichung

4-methyl-2-(3-methyl-but-2-enyloxy)aniline

3-methylbut-2-en-1-ol

3-fluoro-4-nitrotoluene

4-methyl-2-(3-methyl-but-2-enyloxy)aniline

2-aminothiazole

→

3-(3-methyl-but-2-enyloxy)-4-nitrotoluene

Ausbeute 72.0%

1-[4-Methyl-2-(3-methyl-but-2-enyloxy)-phenyl]-3-thiazol-2-yl-urea

Ausbeute 65.0%

Reaktionsbedingungen

Vorschrift

3-(3-methyl-but-2-enyloxy)-4-nitrotoluene (0.8 g, 72%) was prepared from 3-methylbut-2-en-1-ol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-(3-methyl-but-2-enyloxy)aniline (0.43 g, 62%) following general procedure B. 1-[4-Methyl-2-(3-methyl-but-2-enyloxy)-phenyl]-3-thiazol-2-yl-urea (206 mg, 65%) was prepared from 4-methyl-2-(3-methyl-but-2-enyloxy)aniline (191 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.

Quelle