Reaktion #219120

Reaktionsgleichung

2-hydroxythioanisole

2,5-difluoro-1-nitro-benzene

4-fluoro-2-(2-methylsulfanylphenoxy)aniline

2-aminothiazole

→

4-Fluoro-2-(2-methylsulfanylphenoxy)-1-nitrobenzene

Ausbeute 68.0%

1-[4-Fluoro-2-(2-methylsulfanyl-phenoxy)-phenyl]-3-thiazol-2-yl-urea

Ausbeute 60.0%

Reaktionsbedingungen

Vorschrift

4-Fluoro-2-(2-methylsulfanylphenoxy)-1-nitrobenzene (1.06 g, 68%) was prepared from 2-hydroxythioanisole (0.77 g, 5.5 mmol) and 2,5-difluoro-1-nitro-benzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 4-fluoro-2-(2-methanesulfanyl-phenoxy)-phenylamine (0.52 g, 62%) following general procedure C. 1-[4-Fluoro-2-(2-methylsulfanyl-phenoxy)-phenyl]-3-thiazol-2-yl-urea (117 mg, 60%) was prepared from 4-fluoro-2-(2-methylsulfanylphenoxy)aniline (125 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

Quelle